Randomized Observation Periods for the Compound Poisson Risk Model: Dividends

In the framework of the classical compound Poisson process in collective risk theory, we study a modification of the horizontal dividend barrier strategy by introducing random observation times at which dividends can be paid and ruin can be observed. This model contains both the continuous-time and the discrete-time risk model as a limit and represents a certain type of bridge between them which still enables the explicit calculation of moments of total discounted dividend payments until ruin. Numerical illustrations for several sets of parameters are given and the effect of random observation times on the performance of the dividend strategy is studie

Analysis of some risk models involving dependence

The seminal paper by Gerber and Shiu (1998) gave a huge boost to the study of risk theory by not only unifying but also generalizing the treatment and the analysis of various risk-related quantities in one single mathematical function - the Gerber-Shiu expected discounted penalty function, or Gerber-Shiu function in short. The Gerber-Shiu function is known to possess many nice properties, at least in the case of the classical compound Poisson risk model. For example, upon the introduction of a dividend barrier strategy, it was shown by Lin et al. (2003) and Gerber et al. (2006) that the Gerber-Shiu function with a barrier can be expressed in terms of the Gerber-Shiu function without a barrier and the expected value of discounted dividend payments. This result is the so-called dividends-penalty identity, and it holds true when the surplus process belongs to a class of Markov processes which are skip-free upwards. However, one stringent assumption of the model considered by the above authors is that all the interclaim times and the claim sizes are independent, which is in general not true in reality. In this thesis, we propose to analyze the Gerber-Shiu functions under various dependent structures. The main focus of the thesis is the risk model where claims follow a Markovian arrival process (MAP) (see, e.g., Latouche and Ramaswami (1999) and Neuts (1979, 1989)) in which the interclaim times and the claim sizes form a chain of dependent variables. The first part of the thesis puts emphasis on certain dividend strategies. In Chapter 2, it is shown that a matrix form of the dividends-penalty identity holds true in a MAP risk model perturbed by diffusion with the use of integro-differential equations and their solutions. Chapter 3 considers the dual MAP risk model which is a reflection of the ordinary MAP model. A threshold dividend strategy is applied to the model and various risk-related quantities are studied. Our methodology is based on an existing connection between the MAP risk model and a fluid queue (see, e.g., Asmussen et al. (2002), Badescu et al. (2005), Ramaswami (2006) and references therein). The use of fluid flow techniques to analyze risk processes opens the door for further research as to what types of risk model with dependency structure can be studied via probabilistic arguments. In Chapter 4, we propose to analyze the Gerber-Shiu function and some discounted joint densities in a risk model where each pair of the interclaim time and the resulting claim size is assumed to follow a bivariate phase-type distribution, with the pairs assumed to be independent and identically distributed (i.i.d.). To this end, a novel fluid flow process is constructed to ease the analysis. In the classical Gerber-Shiu function introduced by Gerber and Shiu (1998), the random variables incorporated into the analysis include the time of ruin, the surplus prior to ruin and the deficit at ruin. The later part of this thesis focuses on generalizing the classical Gerber-Shiu function by incorporating more random variables into the so-called penalty function. These include the surplus level immediately after the second last claim before ruin, the minimum surplus level before ruin and the maximum surplus level before ruin. In Chapter 5, the focus will be on the study of the generalized Gerber-Shiu function involving the first two new random variables in the context of a semi-Markovian risk model (see, e.g., Albrecher and Boxma (2005) and Janssen and Reinhard (1985)). It is shown that the generalized Gerber-Shiu function satisfies a matrix defective renewal equation, and some discounted joint densities involving the new variables are derived. Chapter 6 revisits the MAP risk model in which the generalized Gerber-Shiu function involving the maximum surplus before ruin is examined. In this case, the Gerber-Shiu function no longer satisfies a defective renewal equation. Instead, the generalized Gerber-Shiu function can be expressed in terms of the classical Gerber-Shiu function and the Laplace transform of a first passage time that are both readily obtainable. In a MAP risk model, the interclaim time distribution must be phase-type distributed. This leads us to propose a generalization of the MAP risk model by allowing for the interclaim time to have an arbitrary distribution. This is the subject matter of Chapter 7. Chapter 8 is concerned with the generalized Sparre Andersen risk model with surplus-dependent premium rate, and some ordering properties of certain ruin-related quantities are studied. Chapter 9 ends the thesis by some concluding remarks and directions for future research

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism arrays. Using data for schizophrenia from the Psychiatric Genomics Consortium (n = 21,868), Keller et al. (2012) estimated that the odds of developing schizophrenia increased by approximately 17% for every additional percent of the genome that is autozygous (β = 16.1, CI(β) = [6.93, 25.7], Z = 3.44, p = 0.0006). Here we describe replication results from 22 independent schizophrenia case-control datasets from the Psychiatric Genomics Consortium (n = 39,830). Using the same ROH calling thresholds and procedures as Keller et al. (2012), we were unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data, although the effect was in the predicted direction, and the combined (original + replication) dataset yielded an attenuated but significant relationship between Froh and schizophrenia (β = 4.86,CI(β) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

J. Lönnqvist on työryhmän Psychiat Genomics Consortium jäsen.Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score regression (LDSC) and genomic restricted maximum likelihood (GREML). The massively reduced computing burden of LDSC compared to GREML makes it an attractive tool, although the accuracy (i.e., magnitude of standard errors) of LDSC estimates has not been thoroughly studied. In simulation, we show that the accuracy of GREML is generally higher than that of LDSC. When there is genetic heterogeneity between the actual sample and reference data from which LD scores are estimated, the accuracy of LDSC decreases further. In real data analyses estimating the genetic correlation between schizophrenia (SCZ) and body mass index, we show that GREML estimates based on similar to 150,000 individuals give a higher accuracy than LDSC estimates based on similar to 400,000 individuals (from combinedmeta-data). A GREML genomic partitioning analysis reveals that the genetic correlation between SCZ and height is significantly negative for regulatory regions, which whole genome or LDSC approach has less power to detect. We conclude that LDSC estimates should be carefully interpreted as there can be uncertainty about homogeneity among combined meta-datasets. We suggest that any interesting findings from massive LDSC analysis for a large number of complex traits should be followed up, where possible, with more detailed analyses with GREML methods, even if sample sizes are lesser.Peer reviewe

A generalized penalty function in Sparre Andersen risk models with surplus-dependent premium

In a general Sparre Andersen risk model with surplus-dependent premium income, the generalization of Gerber-Shiu function proposed by Cheung et al. (2010a) is studied. A general expression for such Gerber-Shiu function is derived, and it is shown that its determination reduces to the evaluation of a transition function which is independent of the penalty function. Properties of and explicit expressions for such a transition function are derived when the surplus process is subject to (i) constant premium; (ii) a threshold dividend strategy; or (iii) credit interest. Extension of the approach is discussed for an absolute ruin model with debit interest.Generalized penalty function Gerber-Shiu function Sparre Andersen model Surplus-dependent premium rate Threshold dividend strategy Credit interest Absolute ruin

A generalized penalty function with the maximum surplus prior to ruin in a MAP risk model

In this paper, a risk model where claims arrive according to a Markovian arrival process (MAP) is considered. A generalization of the well-known Gerber-Shiu function is proposed by incorporating the maximum surplus level before ruin into the penalty function. For this wider class of penalty functions, we show that the generalized Gerber-Shiu function can be expressed in terms of the original Gerber-Shiu function (see e.g. [Gerber, Hans U., Shiu, Elias, S.W., 1998. On the time value of ruin. North American Actuarial Journal 2(1), 48-72]) and the Laplace transform of a first passage time which are both readily available. The generalized Gerber-Shiu function is also shown to be closely related to the original Gerber-Shiu function in the same MAP risk model subject to a dividend barrier strategy. The simplest case of a MAP risk model, namely the classical compound Poisson risk model, will be studied in more detail. In particular, the discounted joint density of the surplus prior to ruin, the deficit at ruin and the maximum surplus before ruin is obtained through analytic Laplace transform inversion of a specific generalized Gerber-Shiu function. Numerical illustrations are then examined.Gerber-Shiu function Generalized penalty function Maximum surplus level before ruin Markovian arrival process Discounted joint distribution

Structural properties of Gerber-Shiu functions in dependent Sparre Andersen models

The structure of various Gerber-Shiu functions in Sparre Andersen models allowing for possible dependence between claim sizes and interclaim times is examined. The penalty function is assumed to depend on some or all of the surplus immediately prior to ruin, the deficit at ruin, the minimum surplus before ruin, and the surplus immediately after the second last claim before ruin. Defective joint and marginal distributions involving these quantities are derived. Many of the properties in the Sparre Andersen model without dependence are seen to hold in the present model as well. A discussion of Lundberg's fundamental equation and the generalized adjustment coefficient is given, and the connection to a defective renewal equation is considered. The usual Sparre Andersen model without dependence is also discussed, and in particular the case with exponential claim sizes is considered.Defective renewal equation Compound geometric distribution Ladder height Lundberg' s fundamental equation Generalized adjustment coefficient Cramer' s asymptotic ruin formula Esscher transform Last interclaim time NWU NBU